I-1,3-Dihydroxyacetone Izindlela Zokukhiqiza Nezicelo Isingeniso CAS 96-26-4

I-1,3-Dihydroxyacetone Isingeniso

I-1,3-Dihydroxyacetone iyinhlanganisela ye-organic ene-molecular formula C3H6O3, okuyi-polyhydroxyketose kanye ne-ketose elula kakhulu.Ukubonakala kuyikristalu emhlophe eyimpuphu, encibilika kalula kuzincibilikisi zemvelo ezifana namanzi, i-ethanol, i-ether, ne-acetone.Iphuzu elincibilikayo lingu-75-80 ℃, futhi ukuncibilika kwamanzi kungu->250g/L (20 ℃).Inokunambitheka okumnandi futhi izinzile ku-pH 6.0.I-1,3-Dihydroxyacetone ushukela onciphisa.Wonke ama-monosaccharides (inqobo nje uma kukhona i-aldehyde yamahhala noma amaqembu e-ketone carbonyl) anokuncipha.I-Dihydroxyacetone ihlangabezana nalezi zimo ezingenhla, ngakho-ke ingeyesigaba sokunciphisa ushukela.

Ikakhulukazi kunezindlela zokuhlanganisa amakhemikhali nezindlela zokuvutshelwa kwe-microbial.Kunezindlela ezintathu zamakhemikhali eziyinhloko ze-1,3-dihydroxyacetone: i-electrocatalysis, i-metal catalytic oxidation, kanye ne-formaldehyde condensation.Ukukhiqizwa kwamakhemikhali e-1,3-dihydroxyacetone kusesesigabeni socwaningo lwaselabhorethri.Ukukhiqizwa kwe-1,3-dihydroxyacetone ngendlela yebhayoloji kunezinzuzo eziphawulekayo: ukugxila komkhiqizo ophezulu, izinga eliphezulu lokuguqulwa kwe-glycerol kanye nezindleko eziphansi zokukhiqiza.Ukukhiqizwa kwe-1,3-dihydroxyacetone e-china nakwamanye amazwe ikakhulukazi kusebenzisa indlela yokuguqulwa kwe-microbial ye-glycerol.

Indlela yokwenziwa kwamakhemikhali

1. I-1,3-dihydroxyacetone ihlanganiswa kusuka ku-1,3-dichloroacetone ne-ethylene glycol njengezinto zokusetshenziswa eziyinhloko ngokuvikelwa kwe-carbonyl, i-etherification, i-hydrogenolysis, ne-hydrolysis.I-1,3-dichloroacetone ne-ethylene glycol ziyashiswa futhi zifakwe kabusha ku-toluene ukuze zikhiqize i-2,2-dichloromethyl-1,3-dioxolane.Bese besabela nge-sodium benzylidene ku-N, i-N-dimethylformamide ukukhiqiza i-2,2-dibenzyloxy-1,3-dioxolane, bese i-hydrogenated ngaphansi kwe-Pd/C catalysis ukuze ihlanganise i-1,3-dioxolane-2,2-dimethanol, okuyinto bese i-hydrolyzed ku-hydrochloric acid ukukhiqiza i-1,3-dihydroxyacetone.Izinto ezisetshenziswayo zokwenziwa kwe-1,3-dihydroxyacetone usebenzisa le ndlela kulula ukuzithola, izimo zokusabela zithambile, futhi i-catalyst ye-Pd/C ingabuyekezwa, enenani lesicelo esibalulekile.

2. I-1,3-dihydroxyacetone yahlanganiswa kusuka ku-1,3-dichloroacetone ne-methanol ngokuvikelwa kwe-carbonyl, i-etherification, i-hydrolysis, kanye nokusabela kwe-hydrolysis.I-1,3-dichloroacetone isabela nge-methanol e-anhydrous eyeqile lapho kukhona okumunca ukukhiqiza i-2,2-dimethoxy-1,3-dichloropropane, ebese ishiselwa nge-sodium benzylate ku-N, N-dimethylformamide ukukhiqiza i-2,2-dimethoxy. -1,3-dibenzyloxypropane.Khona-ke i-hydrogenated ngaphansi kwe-Pd/C catalysis ukukhiqiza i-2,2-dimethoxy-1,3-propanediol, bese i-hydrolyzed ku-hydrochloric acid ukukhiqiza i-1,3-dihydroxyacetone.Lo mzila uthatha indawo yesivikeli se-carbonyl kusuka ku-ethylene glycol kuya ku-methanol, okwenza kube lula ukuhlukanisa nokuhlanza umkhiqizo we-1,3-dihydroxyacetone, onokuthuthuka okubalulekile kanye nenani lesicelo.

3. Ukwenziwa kwe-1,3-dihydroxyacetone kusetshenziswa i-acetone, i-methanol, i-chlorine noma i-bromine njengezinto zokusetshenziswa eziyinhloko.I-acetone, i-anhydrous methanol, negesi ye-chlorine noma i-bromine isetshenziselwa ukukhiqiza i-2,2-dimethoxy-1,3-dichloropropane noma i-1,3-dibromo-2,2-dimethoxypropane ngenqubo yebhodwe elilodwa.Bese benziwa i-etherified nge-sodium benzylate ukuze bakhiqize i-2,2-dimethoxy-1,3-dibenzyloxypropane, esuke i-hydrogenated futhi i-hydrolyzed ukukhiqiza i-1,3-dihydroxyacetone.Lo mzila unezimo zokusabela ezithambile, futhi ukusabela "kwebhodwe elilodwa" kugwema ukusetshenziswa kwe-1,3-dichloroacetone ebizayo futhi ecasulayo, okuyenza ibe yindleko ephansi futhi ibaluleke kakhulu ekuthuthukisweni.

Izinhlelo zokusebenza

I-1,3-Dihydroxyacetone i-ketose eyenzeka ngokwemvelo engaboli, edlekayo, futhi engenabuthi emzimbeni womuntu kanye nendawo ezungezile.Kuyisithasiselo esisebenza ngezinto eziningi esingasetshenziswa ezimbonini zezimonyo, ezemithi, nezokudla.

Isetshenziswa embonini yezimonyo

I-1,3-Dihydroxyacetone isetshenziswa ngokuyinhloko njengesithako sefomula ezimonyoni, ikakhulukazi njengesikhuseli selanga esinemiphumela ekhethekile, engavimbela ukuhwamuka ngokweqile komswakama wesikhumba, futhi ibambe iqhaza ekunyakaziseni, ekuvikeleni ilanga, nasekuvikeleni imisebe ye-UV.Ngaphezu kwalokho, amaqembu asebenzayo e-ketone ku-DHA angasabela ngama-amino acid kanye namaqembu e-amino e-keratin yesikhumba ukuze enze i-polymer ensundu, okwenza isikhumba sabantu sikhiqize umbala onsundu wokwenziwa.Ngakho-ke, ingasetshenziswa futhi njengesifanisi sokuchayeka elangeni ukuze kutholwe isikhumba esinsundu noma esinsundu esibukeka sifana nomphumela wokuchayeka isikhathi eside ekukhanyeni kwelanga, okusenza sibukeke sihle.

Thuthukisa amaphesenti enyama yezingulube

I-1,3-I-Dihydroxyacetone iwumkhiqizo ophakathi we-metabolism kashukela, idlala indima ebalulekile enqubweni ye-metabolism kashukela, ukunciphisa amafutha omzimba wengulube kanye nokwenza ngcono amaphesenti enyama enomzimba.Izisebenzi zesayensi nezobuchwepheshe zaseJapane zibonise ngokuhlolwa ukuthi ukwengeza inani elithile le-DHA kanye nengxube ye-pyruvate (usawoti we-calcium) ekudleni kwezingulube (ngesilinganiso sesisindo esingu-3:1) kunganciphisa okuqukethwe kwamafutha enyama yengulube ngo-12% I-15%, kanye nokuqukethwe kwamafutha enyameni yomlenze kanye nomsipha omude kunawo wonke emuva kuyancishiswa ngokufanayo, nokwanda kokuqukethwe kwamaprotheni.

Okokudla okusebenzayo

Ukwengeza i-1,3-dihydroxyacetone (ikakhulukazi ehlanganiswe ne-pyruvate) kungathuthukisa izinga lomzimba kanye ne-fatty acid oxidation, okungenzeka kushise amafutha ukuze kuncishiswe amafutha omzimba futhi kubambezele ukukhula kwesisindo (umphumela wokulahlekelwa isisindo), futhi kunciphise izinga lokudla. izifo ezihlobene.Kungaphinde kuthuthukise ukuzwela kwe-insulin futhi kunciphise izinga le-cholesterol eplasma elibangelwa ukudla okuphezulu kwe-cholesterol.Ukwengezwa kwesikhathi eside kungakhuphula izinga lokusebenzisa ushukela wegazi futhi konge i-muscle glycogen, Kubasubathi, kungathuthukisa ukusebenza kwabo kokukhuthazela kwe-aerobic.

Okunye ukusetshenziswa

I-1,3-dihydroxyacetone nayo ingasetshenziswa ngokuqondile njenge-reagent ye-antiviral.Isibonelo, esikweni lombungu wezinkukhu, ukusetshenziswa kwe-DHA kungavimbela kakhulu ukutheleleka kwegciwane le-chicken distemper, libulale amaphesenti angama-51 kuya kwangu-100 egciwane.Embonini yesikhumba, i-DHA ingasetshenziswa njenge-ejenti yokuvikela yemikhiqizo yesikhumba.Ngaphezu kwalokho, izivimbelakuvunda ikakhulukazi ezakhiwe yi-DHA zingasetshenziselwa ukulondolozwa nokugcinwa kwezithelo nemifino, imikhiqizo yasemanzini, nemikhiqizo yenyama.