Umkhiqizo: 2-phenylacetamide
Ifomula yemolekyuli: C8H9NO
Isisindo se-molecule: 135.17
Igama lesiNgisi: Phenylacetamide
Umlingiswa: Ikhekheba elimhlophe noma amakristalu amise okweqabunga.Mp 157-158 ℃, bp 280-290 ℃ (ukubola).Incibilika emanzini ashisayo ne-ethanol, inyibilika kancane emanzini abandayo, i-ether, ne-benzene.
Ukusetshenziswa: Okumaphakathi kwezidakamizwa ezifana ne-penicillin ne-phenobarbital.Ibuye isetshenziselwe ukulungiswa kwe-phenylacetic acid, izinongo, nezibulala-zinambuzane.
Indlela 1) UMasuko F，Katsura T.US 4536599A1.1985.
Engeza u-117.2 g (1.0 mol) we-phenylacetonitrile (2), 56.1 g wesisombululo esingu-25% se-potassium hydroxide, u-291.5 g we-35% ye-hydrogen peroxide yesisombululo esinamanzi, 1.78 g we-benzyltriethylammonium chloride, kanye no-351.5 g we-isopropanoskGovuza futhi usabele ku-50 ℃ amahora angu-4.Ngemuva kokuthi ukusabela sekuqediwe, i-isopropanol iyahwamuka ngaphansi kwengcindezi encishisiwe, ipholile, ihlungwe, igezwe ngamanzi, futhi yomiswe ukuze kutholwe inhlanganisela (1) 128.5 g, mp 155 ℃, ngesivuno esingu-95%.
Indlela 2) Furniss BS, Hannaford AJ, Rogers V, nabanye.Incwadi kaVogel ye-Practical Chemistry.Longman London naseNew York.Inguqulo yesine, 1978:518.
Engeza u-100 g (0.85 mol) we-phenylacetonitrile (2) kanye no-400 mL we-hydrochloric acid egxilile kufulaski wokusabela.Ngaphansi kokunyakaziswa, sabela ku-40 ℃ cishe imizuzu engama-40, bese ukhuphula izinga lokushisa libe ngu-50 ℃.Qhubeka nokusabela imizuzu engama-30.Phola ufike ku-15 ℃ bese wengeza u-400 mL wamanzi abandayo acwecwe ngokwehla.Ukupholisa emanzini okugeza e-ice, kuhlunga amakristalu.Engeza okuqinile ku-50 mL wamanzi bese ugoqa kahle ukuze ususe i-phenylacetic acid.Hlunga futhi womise ku-50-80 ℃ ukuze uthole u-95 g we-phenylacetamide (1), mp 154-155 ℃, ngesivuno esingu-82%.Ukwenziwa kabusha nge-ethanol, mp 156 ℃.
Isikhathi sokuthumela: Apr-11-2023