Singabanye abahamba phambiliabahlinzeki be-n-methylbenzamidekanye nabakhiqizi e-china, uma ufuna ukutholai-n-methylbenzamide factory, zizwe ukhululekile ukuxhumana nathi futhi usithumelele i-imeyili.
1. YiniN-Methylbenzamide?
I-N-methylbenzamide iyi-phosphodiesterase 10A (pde10a) inhibitor esebenzayo.I-N-methylbenzamide inomsebenzi wokulwa nomdlavuza.I-PDE10A iyi-phosphodiesterase esanda kukhonjwa enendawo ephawulekayo njengoba iphrotheni igcwele ezicutshini zobuchopho kuphela.Ngokusekelwe kulokhu kutholakala kwasendaweni okuyingqayizivele, ucwaningo lugxile kakhulu ekusebenziseni ama-modulators e-PDE10A njengendlela yokwelapha inoveli yokungasebenzi kahle kwesekethe ye-basal ganglia okuhlanganisa nesifo sika-Parkinson, isifo sika-Huntington, i-schizophrenia, ukulutheka kanye nokuphazamiseka kwengqondo okuphoqelekile.Imizamo yekhemikhali yezokwelapha ihlonze i-N-methyl-N- [4-(quinolin-2-ylmethoxy)-phenyl] -isonicotinamide njenge-nanomolar PDE10A inhibitor.Uhlelo olwalandela lwe-Lead-optimization luhlonze i-N-methylanilides efanayo kanye ne-N-methylbenzamide ehambisana nayo njengezinqamuleli ezinamandla ze-PDE10A, ngesikhathi esifanayo ezinye izindlela zokubopha ezithakazelisayo nezingalindelekile zihlonziwe.
Iphoyinti lokuncibilika 76-78 ° C
Iphoyinti lokubilisa 167 ° C
Ukuminyana 1.1031
Inkomba ye-Refractive 1.5589
Izimo zokugcina zivaliwe zomile, izinga lokushisa legumbi
I-ethanol encibilikayo: i-soluble 50mg/ml,ukuncibilika kwamanzi:Ayincibiliki emanzini
I-CAS:613-93-4
Ukubukeka: I-Crystalline Emhlophe
2. Isicelo Main
I-inhibitor, i-anticancer, i-organic synthesis intermediate, amakhemikhali aselabhorethri
3.Isitoreji Nokupakisha
3.Izinyathelo zosizo lokuqala
Ukuthintana Kwamehlo: Hlanza ngokushesha ngamanzi amaningi, nangaphansi kwamajwabu amehlo, okungenani imizuzu eyi-15.Thola usizo lwezempilo.
Ukuthinta Isikhumba: Geza ngokushesha ngensipho namanzi amaningi kuyilapho ususa zonke izingubo nezicathulo ezingcolile.
Ukuhogela: Susa ekuchayekeni, lala phansi.Khipha emoyeni omusha.Uma ungaphefumuli, nikeza ukuphefumula okwenziwa.
Ukungenisa: Hlanza umlomo ngamanzi.Thola usizo lwezempilo.
Izimpawu nemiphumela ebaluleke kakhulu: Alukho ulwazi olutholakalayo.
Ukuzivikela Kosizo Lokuqala: Azikho izinyathelo zokuphepha ezikhethekile ezidingekayo.
Amanothi kaDokotela: Yelapha ngendlela ekhombisa izimpawu.
4. Ulwazi lwezokuthutha
Ezokuthutha Ngomgwaqo Nezitimela : Azilawulwa
I-IMDG/IMO : Ayilawulwa
I-IATA : Ayilawulwa
Ukuqapha Okukhethekile Komsebenzisi: Azikho izinyathelo zokuphepha ezikhethekile ezidingekayo
5. I-HTML5 spectrum
I-Hebei Guanlang Biotechnology Co., Ltd. ingeye-Guanlang Group, eyasungulwa ngo-2007, etholakala edolobheni laseShijiazhuang okuyinhloko-dolobha yesiFundazwe sase-Hebei kanye nomkhakha wehabhu phakathi kweBeijing Tianjin ne-Hebei futhi inenzuzo yokuhamba kalula.Inkampani yethu iyibhizinisi lamakhemikhali lesimanje elinobuchwepheshe obuphezulu elinoCwaningo Nokuthuthukiswa, ukukhiqiza nokuthengisa.
