Kusukela ngonyaka ka-2007, singabanye abahamba phambilii-orlistat powderumphakeli womkhiqizi e-china
I-Orlistat (CAS NO.96829-58-2) iyisidakamizwa esenzelwe ukwelapha ukukhuluphala.Isetshenziselwa ikakhulukazi ukuvimbela ukumuncwa kwamafutha ekudleni komuntu, ngaleyo ndlela kuncishiswe ukudla kwe-caloric.Ngaphandle kwalokho, ihloselwe ukusetshenziswa ngokuhambisana nokudla okuncishisiwe okugadwa udokotela.
| Into | Izimfuneko | Imiphumela Yokuhlola |
| Ukubukeka | ngenkathi i-off-ngenkathi i-powder | Impushana emhlophe |
| Ukuhlonza | Isikhathi sokugcina se-HPLC | Kuyavumelana |
| I-Melting Point | 42 ºC -45°C | 42°C-44°C |
| Ukujikeleza kwe-optical okuqondile | -31.0°~-41.0° | -36.0° |
| Ukuhlanzeka kwe-HPLC | hhayi ngaphansi kuka-98.0% | 98.5% |
| Ukungcola okuphelele | akukho ngaphezu kuka-2.0% | 1.6% |
| Ukungcola Okukhulu Komuntu Ngamunye | akukho ngaphezu kuka-0.5% | 0.3% |
| Okuqukethwe kwamanzi%(K&F) | akukho ngaphezu kuka-0.5% | 0.1% |
| Izincibilikisi ezisele | I-EtOH ayikho ngaphezu kuka-0.5% | ND |
| I-EtAC ayikho ngaphezu kuka-0.5% | ND | |
| n-Heptane akukho ngaphezu kuka-0.5% | ngaphansi kuka-0.1% | |
| Izinsalela ekushiseni | ngaphansi kuka-0.2% | 0.10% |
| Izinsimbi ezinzima njenge-Pb | akukho ngaphezu kwe-20ppm | ngaphansi kuka-20ppm |
| I-Assay (HPLC) | hhayi ngaphansi kuka-98.0% | 99.60% |
| Isiphetho | Ihlangabezana Nezimfuneko | |
I-Orlistat iwuhlobo olusha oluqashelwa umhlaba wonke lomuthi wokwehlisa isisindo.Igama layo lezentengiselwano i-Sainike futhi laqala ukudayiswa eNew Zealand ngo-1998. I-Orlistat iyi-lipase inhibitor yesikhathi eside futhi esebenza kahle kakhulu, futhi ayincibiliki emanzini, i-chloroform, futhi incibilika kalula ku-ethanol.
I-Orlistat ingasetshenziswa emtholampilo ukwelapha ukukhuluphala.Ngokuvamile, umthamo we-120mg uthathwa kathathu ngosuku phakathi nehora elilodwa lokudla.Ukuncipha kwesisindo kuqala ukwenzeka ngemva kwamasonto amabili okusetshenziswa.Ingasetshenziswa ngokuqhubekayo izinyanga ezingu-6-12, futhi imiphumela yayo izoyeka ukwanda ngemva kokuba umthamo wansuku zonke udlule u-400mg.Lesi sidakamizwa sifaneleka ukuba sisetshenziswe ngokuhambisana nokudla okunekhalori ephansi ngabantu abakhuluphele nabakhuluphele ngokweqile, futhi singasetshenziswa njengokwelashwa kwesikhathi eside ezigulini eziye zabhekana nezici eziyingozi ezihlobene nesisindo.I-Orlistat inomphumela wesikhathi eside wokulawula isisindo esinciphisa futhi sigcine isisindo futhi sivimbele ukuphindaphinda.Ukusebenzisa i-Orlistat kunganciphisa ukwenzeka kwezinto eziyingozi ezihlobene nesisindo kanye nezifo, okuhlanganisa i-hypercholesterolemia, isifo sikashukela sohlobo lwe-2, ukubekezelela i-glucose ukukhubazeka, i-hyperinsulinemia, nomfutho wegazi ophakeme, futhi kunganciphisa okuqukethwe kwamafutha ezithweni.I-Orlistat iphinde ilungise amazinga e-lipid egazi: inganciphisa i-serum triglycerides (TG) kanye ne-low density lipoprotein cholesterol (LDL-C), futhi ingakhuphula isilinganiso sama-lipoprotein aphezulu kakhulu kuya ku-low density lipoprotein ezigulini ezikhuluphele.
I-Hebei Guanlang Biotechnology Co., Ltd. ingeye-Guanlang Group, eyasungulwa ngo-2007, etholakala edolobheni laseShijiazhuang okuyinhloko-dolobha yesiFundazwe sase-Hebei kanye nomkhakha wehabhu phakathi kweBeijing Tianjin ne-Hebei futhi inenzuzo yokuhamba kalula.Inkampani yethu iyibhizinisi lamakhemikhali lesimanje elinobuchwepheshe obuphezulu elinoCwaningo Nokuthuthukiswa, ukukhiqiza nokuthengisa.
